Here, we describe the emergence of a new SARS-CoV-2 lineage, mainly from the Central Visayas region of the Philippines. This emergent variant is characterized by 13 lineage-defining mutations, including the co-occurrence of the E484K, N501Y, and P681H mutations at the spike protein region, as well as three additional radical amino acid replacements towards the C-terminal end of the said protein. A three-amino acid deletion at positions 141 to 143 (LGV141_143del) in the spike protein was likewise seen in a region preceding the 144Y deletion found in the B.1.1.7 variant. A single amino acid replacement, K2Q, at the N-terminus of ORF8 was also shared by all 33 samples sequenced.
WSJ: “The World Health Organization team investigating the origins of Covid-19 is planning to scrap an interim report on its recent mission to China amid mounting tensions between Beijing and Washington over the investigation and an appeal from one international group of scientists for a new probe. A group of two dozen scientists is calling in an open letter on Thursday for a new international inquiry. They say the WHO team that last month completed a mission to Wuhan—the Chinese city where the first known cases were found—had insufficient access to adequately investigate possible sources of the new coronavirus, including whether it slipped from a laboratory.”
“An orangutan named Karen, the first in the world to have open-heart surgery in 1994, has made medical history again: She’s among the first great apes to get a COVID-19 vaccine.
“Given a growing number of COVID-19 cases on the Island, particularly amongst children, all of the Island’s schools, nurseries and childminders will be closed tomorrow (Friday 5 March).
Over 450 cases of the South Africa coronavirus variant 501Y.V2 have been diagnosed in Israel so far, and health professionals estimate that dozens more are being infected each day.
The Deputy Chief Medical Officer has said that NPHET has been made aware of four preliminary reports of stillbirths in Ireland, that could potentially be associated with a condition called Covid Placentitis.
“We have also observed delayed large local reactions to the mRNA-1273 vaccine, with a median onset on day 8 (range, 4 to 11) after the first dose. These reactions had a variable appearance. Here, we report on a series of 12 patients with these reactions, all of which appeared near the injection site after complete resolution of the initial local and systemic symptoms associated with vaccination.”
Sixteen cases of a new variant, VUI-202102/04 (lineage B.1.1.318), have been identified in the UK. The variant has been designated a Variant Under Investigation (VUI) by Public Health England (PHE).
A new study has shown people previously infected by the Covid-19 variant 501Y.V2, originally identified in South Africa, have better immunity against other coronavirus mutations, experts said Wednesday.
“You must not judge us yet”, said Anders Tegnell in the spring of 2020, while the whole world looked at the open Swedish strategy and the accompanying high death toll.
Vita Laboratories and the University of Helsinki report that the variant Fin-796H has now been found in another patient. Both confirmed infections are related to the same chain of infection.
Denmark’s SSI: The Technical University of Denmark, DTU, has found a case of the P1 variant, which was originally detected in Brazil.