Tag: ACE2

Preprint: Coronaviruses with a SARS-CoV-2-like RBD isolated from bats of the Indochinese peninsula

“We found that the RBDs of these viruses differ from that of SARS-CoV-2 by only one or two residues”

Here we show that such viruses indeed circulate in cave bats living in the limestone karstic terrain in North Laos, within the Indochinese peninsula.  More...

Coronaheadsup.com Animals, Asia, China, Coronavirus, Infection, Laos, Origins, Reservoir, Transmission

UK SAGE: Lab studies suggest that the N501Y spike protein mutation increases binding to rat and mouse ACE2 leading to viral replication

A report issued by the UK government’s Scientific Advisory Group for Emergencies (SAGE) found the likelihood that a variant of concern (VOC) that has arisen in humans could infect a rodent and then spread among the animals is high.  More...

Coronaheadsup.com Animals, B.1.1.7, B.1.351, Coronavirus, England, Health, Infection, London, N501Y, Northern Ireland, P.1, Reservoir, Science, Scotland, Testing, Transmission, UK, Wales

Circulating SARS-CoV-2 variants B.1.1.7, 501Y.V2, and P.1 have gained ability to utilize rat and mouse Ace2 and altered in vitro sensitivity to neutralizing antibodies and ACE2-Ig

Here, we first investigated cross-species receptor usage of multiple SARS-CoV-2 variants that emerged during the pandemic.  More...

Coronaheadsup.com Africa, America, Animals, B.1.1.7, B.1.351, Brazil, Coronavirus, England, Europe, Health, Infection, Mutation, N501Y, P.1, Reinfection, Science, Scotland, South Africa, UK, Vaccine, Variants, Wales