During the study period, 490 [child] patients were admitted and diagnosed with suspected and probable COVID-19. Of these patients, 50 (10.2%) were confirmed to have COVID-19, and 20 (40%) had a fatal outcome.
The fatality rate was higher in patients aged ≥10 years, categorized with severe disease upon admission, PaO2/FiO2 ratio ≤300 mmHg and chronic underlying diseases. The most common clinical manifestations were generalized symptoms, while acute respiratory distress syndrome (8/20) and septic shock (7/20) were the two most common causes of death. Increased procalcitonin, D-dimer, lactate dehydrogenase and presepsin levels were found in all fatal cases. One patient met the criteria of multisystem inflammatory syndrome in children.
Conclusion: Our work highlights the high mortality rate in paediatric patients with positive SARS-CoV-2 polymerase chain reaction test. These findings might be related to or co-incided with COVID-19 infection. Further studies are needed to improve understanding of the role of severe acute respiratory syndrome coronavirus-2 in elaborating the mechanisms leading to death in children with comorbidities.
NYtimes report: Children Are Dying as Virus Surges in Indonesia – hundreds have died from Covid-19 in recent weeks, many of them under the age of 5.
There is a significant risk of “vaccine breakthrough” with the Sinovac vaccine, or CoronaVac, with international evidence showing that many who had taken it were later infected with COVID-19, said the Ministry of Health’s (MOH) director of medical services Kenneth Mak on Friday, 18 June 2021.
Associate Professor Kenneth Mak said that Singapore has been assessing the experience of countries such as Indonesia, which has vaccinated a “larger proportion” of the population using CoronaVac.
More than 350 doctors and medical workers have caught COVID-19 in Indonesia despite being vaccinated with Sinovac. Dozens have been hospitalised. Most of the workers were asymptomatic and self-isolating at home but dozens were in hospital with high fevers and falling oxygen-saturation levels.