USA: Covid-19 can infect testes; evidence of direct infection in organ by #Coronavirus found

Researchers at the University of Texas Medical Branch have observed that SARS-CoV-2, the virus that causes COVID-19, can infect the testes of infected hamsters. The findings, published in the journal Microorganisms, could help explain symptoms some men with COVID-19 have reported and have important implications for men’s health.

Some patients have reported testicular pain and some reports have shown decreases in testosterone, a key hormone produced in the testes. Autopsies have also shown significant disruption of the testes at the cellular level, including the presence of immune cells.

“Given the magnitude of the COVID-19 pandemic, it is critical to investigate how this disease can impact the testes, and the potential consequences for disease severity, reproductive health, and sexual transmission,” said Dr. Rafael Kroon Campos, the study’s lead author and postdoctoral fellow in the laboratory of Dr. Shannan Rossi at UTMB.

Eurekalert.org report

 

 

Image by Gordon Johnson from Pixabay

Progesterone therapy may improve #coronavirus outcomes for men

Clinical Trial at Cedars-Sinai Suggests Injections of Female Hormone May Reduce Disease Severity in Certain Male Patients

COVID-19 disproportionately affects men compared with women, raising the possibility that a hormone like progesterone may improve clinical outcomes for certain hospitalized men with the disease. New research from Cedars-Sinai published online in the journal Chest supports this hypothesis.

The pilot clinical trial, involving 40 men, is believed to be the first published study to use progesterone to treat male COVID-19 patients whose lung functions have been compromised by the coronavirus. While the findings are promising, larger clinical trials are needed to establish the potential of this experimental therapy, the investigators said.

Cedars-Sinai press release

Preprint Study download – PDF

 

Image by Myriams-Fotos from Pixabay

An imbalance in men’s #testosterone levels was linked to the severity of their #coronavirus case

An imbalance in men’s testosterone levels was linked to the severity of their coronavirus case, a new study has found.

Hypogonadism was 6 times more likely to be found in the coronavirus-groups than the healthy control group. Testosterone levels under 9.2 nmol/L were recorded in 257 corona patients (89.8%), whereas only 42 healthy men (14.9%) tested for such low levels. Overall, the lower testosterone levels predicted higher instances of mortality and critical conditions in the patients.

Editors note: ** We proposed in April 2020 that human hormones were being manipulated by the virus and that there was a noticeable INCREASE in testosterone levels after recovery from COVID-19 infection that lasted for a period of several months **

Jerusalem Post Article

Full scientific paper

 

Image by Ryan McGuire from Pixabay