Tag: Spike
Household transmission of R.1 coronavirus lineage with spike E484K mutation in Japan
In this study, we conducted genetic surveillance and identified R.1 lineage harboring E484K mutation in RBD by whole genome sequencing. More...
Unique protein features of SARS-CoV-2 coronavirus relative to other Sarbecoviruses
“Spike analysis reveals that the current SARS-CoV-2 variants of concern have sampled only 36% of the possible spikes changes which have occurred historically in Sarbecovirus evolution. More...
Israel: new coronavirus variant found, has infected hundreds of people
Scientists have discovered an Israeli coronavirus variant, and believe there are hundreds of cases of the mutation in the north, south and center of the country — but they don’t believe it poses a challenge to vaccine effectiveness. More...
A novel variant of interest of SARS-CoV-2 with multiple spike mutations detected through travel surveillance [Angola/Tanzania]
“We detected a new VOI in three incoming travelers from Tanzania who were tested together at the airport in mid-February. More...
Antibody resistance of coronavirus variants B.1.351 (SA) and B.1.1.7 (UK)
“Findings on B.1.351 [South Africa variant] are more worrisome in that this variant is not only refractory to neutralization by most NTD mAbs but also by multiple individual mAbs to the receptor-binding motif on RBD, largely owing to an E484K mutation. More...
B.1.258∆, a SARS-CoV-2 variant with ∆H69/∆V70 in the Spike protein circulating in the Czech Republic and Slovakia
We analyzed SARS-CoV-2 samples collected from various regions of Slovakia between November and December 2020 that were presumed to contain the B.1.1.7 variant due to traveling history of the virus carriers or their contacts. More...
Robust spike antibody responses and increased reactogenicity in seropositive individuals after a single dose of SARS-CoV-2 mRNA vaccine
“we show that the antibody response to the first vaccine dose in individuals with pre-existing immunity is equal to or even exceeds the titers found in naïve individuals after the second dose. More...
Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity
“SARS-CoV-2 can mutate and evade immunity, with consequences for efficacy of emerging vaccines and antibody therapeutics. More...
Distinct Patterns of Emergence of SARS-CoV-2 Spike variants including N501Y in Columbus, Ohio
“We report here the emergence in Columbus, Ohio in December 2020 of two novel SARS-CoV-2 clade 20C/G variants. More...
Denmark finds 4 coronavirus cases which only have the E484K mutation in the spike protein
The first case of another covid-19 variant has been found in Denmark. More...