Tag: Variant of concern
UK SAGE: Lab studies suggest that the N501Y spike protein mutation increases binding to rat and mouse ACE2 leading to viral replication
A report issued by the UK government’s Scientific Advisory Group for Emergencies (SAGE) found the likelihood that a variant of concern (VOC) that has arisen in humans could infect a rodent and then spread among the animals is high. More...
Brazil: rapid spread and high impact of the coronavirus VOC P.1 in Sao Paulo – March 2021
Here, we show evidence of how fast the VOC P.1 has spread in the most populated city in South America – Sao Paulo. More...
CDC: SARS-CoV-2 Coronavirus Variant Classifications and Definitions including Variant of Interest (VOI), Variant of Concern (VOC) & Variant of High Consequence (VOHC)
Variant of High Consequence (VOHC): A variant of high consequence has clear evidence that prevention measures or medical countermeasures (MCMs) have significantly reduced effectiveness relative to previously circulating variants. More...
Detection of 54 cases of the P.1 variant in Massachusetts in less than a month
All three global VoCs (B.1.1.7, B.1.351, and P.1) have now been detected in MA. More...
Canada: Coronavirus hospitalizations, ICU Admissions and deaths associated with the new variants of concern
New variants of concern (VOCs) now account for 67% of all Ontario SARS-CoV-2 infections. More...
Emergence of a coronavirus SARS-CoV-2 E484K variant of interest in Arizona – VOI B.1.243.1
We sequenced the SARS-CoV-2 genome from 688 positive samples collected from December 28 2020 to March 13 2021 in Arizona, USA. More...
BMJ: B.1.1.7 “in addition to being more transmissible, seems to be more lethal”
Results The mortality hazard ratio associated with infection with VOC-202012/1 compared with infection with previously circulating variants was 1.64 (95% confidence interval 1.32 to 2.04) in patients who tested positive for Covid-19 in the community. More...
SARS-CoV-2 VOC 202012/01 B117 has about twofold replicative advantage and acquires concerning mutations
We have estimated growth rates of expanding mutations acquired by the VOC lineage to find that the L18F substitution in spike has initiated a substrain of high replicative advantage in relation to the remaining VOC substrains. More...
Estimated transmissibility and severity of novel SARS-CoV-2 Variant of Concern 202012/01 in England
“..the increase in transmissibility is likely to lead to a large increase in incidence, with COVID-19 hospitalisations and deaths projected to reach higher levels in 2021 than were observed in 2020, even if regional tiered restrictions implemented before 19 December are maintained”. More...