Preprint: Omicron BA.1 infection in mink leads to symptomatic disease with lung pathology and transmission

Experimental infection of American mink with SARS-CoV-2 Omicron variant BA.1 show that minks remain virus RNA positive for days, develop clinical signs and histopathological changes, and transmit the virus to uninfected recipient.  More...

Preprint: SARS-CoV-2 infects and replicates in human testes

“The virus remains infective after a long infection period in the testes (viral reservoir)”

This is the first study that shows:
1) the high SARS-CoV-2 tropism to the testis
2) one mode of SARS-CoV-2 entrance in testes
3) SARS-CoV-2 preferred infection and replication in spermatogonia and macrophages
4) that the virus remains infective after a long infection period in the testes (viral reservoir)
5) high levels of angiotensin II and activated mast cells and macrophages are critical players in promoting all testicular alterations
6) the more extended severe condition, the lower the number of surviving germ cells
7) fluctuation in several essential testicular genes
8) that the intratesticular testosterone levels are 30 times reduced in testes of COVID-19 patients
9) the prevalent types of collagen present in SARS-CoV-2 mediated testicular fibrosis
10) the fluctuation of vasoconstrictive peptides in testes of COVID-19 critically ill patients

Medrxiv Preprint: SARS-CoV-2 infects, replicates, elevates angiotensin II and activates immune cells in human testes

 

Sars-CoV-2 – checkmate to the virus in four moves

 

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Norway: 248 deaths and nearly 52,000 reports of other Covid vaccine side-effects

From a population of just 5.3 million people, Norway has reported a total of 248 deaths as suspected side effects after a Covid vaccine, according to the latest Adverse Reaction Report from the Norwegian Medicines Agency, published on Thursday, 20th January.  More...